Six players – fullback Blair Murray, flyhalf Dan Edwards, scrum-half Kieran Hardy, hooker and captain Dewi Lake, tighthead prop Keiron Assiratti and full-back Alex Mann – will take part in their fourth tests of the autumn.
The loss of Rogers and Bristol’s Louis Rees-Zammit means Ellis Mee, who was called up to the squad on Monday, and Rio Dyer are selected on the flanks.
Center Joe Roberts and scrum-half Kieran Hardy replace the Gloucester pairing of Max Llewellyn and Tomos Williams.
Gareth Thomas will get his first start of the autumn at loosehead prop, while there is a new second-row partnership of Ben Carter and Rhys Davies.
Ospreys lock James Fender does not have a chance to earn his first cap due to a shoulder injury.
Wainwright’s return means Alex Mann moves to openside at the expense of Harri Deaves and Taine Plumtree moves to blindside flanker.
Cardiff loosehead prop Danny Southworth is in line to make his Test debut from a bench that also includes club-mate Callum Sheedy.
Ten players are set for their first action of the autumn: Mee, Roberts, Dyer, Carter and Davies in the XV and Southworth, prop Chris Coleman, lock James Ratti, scrum-half Reuben Morgan-Williams and Sheedy on the bench.
Tandy said: “What we want to see from the guys is the same kind of effort and performance that we did last weekend.
“I think we showed a lot of attacking intent, a lot of toughness in the way we put in a lot of defensive efforts as well, to give the fans something to shout about.”
