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The Ministry of Science and Technology said on Tuesday that scientists at the Institute of Nano Science and Technology (INST), Mohali, have discovered a new method involving nanoparticles for the treatment of Alzheimer’s disease (AD). This medicine can slow down the disease, improve memory and help in thinking ability.
The Ministry of Science and Technology said on Tuesday that scientists at the Institute of Nano Science and Technology (INST), Mohali, have discovered a new method involving nanoparticles for the treatment of Alzheimer’s disease (AD). This medicine can slow down the disease, improve memory and help in thinking ability. Now the question is, what is Alzheimer’s? How is nanoparticle medicine beneficial in this? Read in detail in research-
What is Alzheimer’s?
Alzheimer’s is a complex disease. In this, protein clumps form in the brain, swelling occurs, oxidative stress increases and brain cells start dying. Old medicines cure only one problem, so there is no complete benefit. The new therapy uses tiny particles made from a combination of three ingredients: a green tea antioxidant (EGCG), the brain chemical dopamine (EDTNP) and the amino acid tryptophan.
To further improve these particles, a protein called BDNF has been added, which helps brain cells to grow and survive. This medicine does many things simultaneously. It breaks down harmful protein clumps in the brain, then reduces inflammation and reduces oxidative stress. Which protects brain cells and helps in creating new ones.
How will it attack the symptoms of Alzheimer’s?
The team led by Dr. Jiban Jyoti Panda (INST, an autonomous institute of DST) has done this research. Panda said, “By combining brain-derived neurotrophic factor (BDNF), a protein essential for the survival, growth and function of neurons, onto edTNP (b- edTNP), a dual-action nanoplatform is created that not only clears neurotoxic amyloid beta aggregates (clusters of protein that negatively impact neural function), but also “Also helps in regeneration.”
This medicine was successful in lab tests and testing on rats. Computer simulations also showed that these particles break down harmful proteins well. Dr. Ashok Kumar Datusalia of NIPER Raebareli and Dr. Neesha Singh of Gujarat Biotechnology University have contributed in this research, which has been published in the world famous journal Small. According to scientists, this new discovery is a great hope for Alzheimer’s patients and their families. Right now it is in the initial stage, more tests will be done further.
