Causative Biomarkers of Depression Identified : In today’s lifestyle, tension and stress have become a part of life. Despite not wanting, they enter your life in some way or the other and if they remain for a long time then you can go into depression. The complexity of the investigation of depression in humans remains a major problem even today. Therefore, it is not recognized on time and then treatment is also delayed, due to which the situation worsens. But a team of researchers from the University of Illinois Chicago developed their new Study A great achievement has been made in the direction of solving this problem. The research team has identified biomarkers of depression in platelets, which will make it easier to detect the severity of the disease. Several previous studies have found a lack of adenylyl cyclase in humans and animal models to lead to a state of depression.
Adenylyl cyclase is a small molecule inside cells that is formed in response to the neurotransmitters serotonin and epinephrine. The findings of this study are published in the journal Molecular Psychiatry. published Has happened.
what the experts say
Professor of Physiology and Biophysics and Psychiatry at the University of Illinois Chicago and the leader of this study Mark Rasenick According to this, when you are depressed the level of adenylyl cyclase is low. This is because a decrease in adenylyl cyclase degrades the intermediate protein that helps make the neurotransmitter adenylyl cyclase- Gsα (Gsα) and is a cholesterol-rich matrix. It sticks to the membrane (lipid raft), where it is unable to do its job properly. During this new study, such cellular biomarkers have been identified, which transfer Gsα from lipid rafts. This biomarker can be identified with a blood test.
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The effect of treatment will also be indicated
Mark Rasenick Told that we have developed such a test, which will not only tell the occurrence of depression, but it will also indicate the effect of treatment with the same biomarker. Researchers believe that through this blood test, they will also be able to find out in just a week whether the antidepressant treatment is working or not. It has been reported in earlier studies that when the symptoms of depression subside, Gsα dissociates from the lipid raft. However, in patients who do not improve despite taking antidepressants, GS continues to stick to Alpha Raft. This means that there is not enough of an antidepressant in the bloodstream to improve symptoms. A blood test will be done after a week of starting the treatment to know whether the GS alpha has detached from the lipid raft or not.
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Since platelets change over a week, it becomes easier to find out which ones are getting better with treatment. With this, we will be able to detect the biomarker from which the treatment will be successful.
how to get benefit
According to Mark Rasenick, at this time patients and doctors have to wait several weeks or months to know whether the antidepressant drug or treatment is working or not. In such a situation, when it comes to the fact that the treatment is not getting the right effect, then immediate alternative treatment can be tried. He told that when about 30% of patients do not get benefit from treatment, then this failure becomes a ladder of further failure and both the doctor and the patient start feeling that nothing is happening. Anyway, the diagnosis of depression This happens in such clinics of doctors, where there is no system of accurate screening. But on the basis of this test, the doctor can say that you look depressed, but their blood does not show it. Therefore, a blood test may be needed again. Mark Rasenick is working closely with his company Pax Neuroscience to develop such screening tests.
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